do glp 1 meds cause muscle loss GLP-1 receptor agonists, which are effective for weight loss, can substantial loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: https://t.co/qQ85u86B1G GLP-1 Medications and Muscle Loss:

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In preclinical studies, the peptide activated melanocortin receptors in the medial preoptic area, leading to increased dopamine signaling and enhanced sexual motivation

This is generally not a cause for concern, but it can change how quickly medication takes effect in some cases

Collectively, these data suggest that pharmacotherapies targeting the GLP1-R might attenuate nicotine-related reinforcement and help limit post-quit rise in body weight