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Human data: Human evidence is limited to a single published Phase I/II pharmacokinetic-pharmacodynamic dose-escalation study in healthy adults

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In diabetic animals, the UDP-glucose levels are low in tissues, and these tissues are hypersensitive to the cytotoxic effects of -toxin through some unknown mechanism (Flores-Daz et al., 1998)

An integrative approach to elucidate mechanisms underlying the pharmacokinetic goldenseal-midazolam interaction: application of in vitro assays and physiologically based pharmacokinetic models to understand clinical observations

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