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Unlike growth hormone peptides (which work through the pituitary) or GLP-1 peptides (which work through gut and brain receptors), BPC-157 works primarily through a different mechanism: it upregulates growth hormone receptors in tendon cells, stimulates angiogenesis (the formation of new blood vessels), and modulates nitric oxide signaling all of which contribute to accelerated tissue repair and reduced inflammation

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It stabilizes intestinal permeability and enhances cytoprotection, making it a promising candidate for mitigating NSAID-induced gastroenteropathy and leaky gut syndrome

Science 348 , aaa2151 (2015)