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Ter vergelijking: bij iemand van 100 kg is dat 24 tot 29 kilo

It is known that the acute HPA response to stress plays an important role and has numerous functions which promote cells survival, but chronic activation of this axis by stressful episodes may lead to a wide range of pathological conditions, including depression

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The experiments employed RAMP1 knockout (KO), RAMP3 KO, and RAMP1/3 double KO mice on a 129S2/SvEv genetic background