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Pegylation does not change the amino acid sequence, but protects the peptide against enzymatic degradation, which extends its half-life under experimental conditions

One of the key aspects of diagnosing this disorder, aside from having a clinical suspicion in the setting of anion gap metabolic acidosis without another explanation, is the detection of 5-oxoproline in the urine

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Alcohol interactions are a common concern, since many patients want to know whether they need to completely abstain while on treatment

Another study revealed that shikonin induces erythrocyte death by influencing Ca 2+ influx and ceramide formation (Lupescu et al., 2014)