Though in acute conditions, this is effective in the short term, it is thought that chronically high levels of ROS-induced oxidative stress may cause severe tissue damage, leading to a number of diseases including inflammatory joint disease, insulin-dependent diabetes mellitus, asthma, cardiovascular disease, and many neurodegenerative diseases, e.g., Alzheimers and amyotrophic lateral sclerosis (ALS or Lou Gehrigs disease a progressive neurodegenerative disorder which affects motor-neuron cells in the brain and the spinal chord, leading ultimately to total paralysis)
In these areas, it helps stabilize cell structures and shields DNA from damage caused by free radicals, which contribute to aging and disease
Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice
Inflammatory bowel disease represents the most advanced clinical target, with at least one Phase II trial having examined a BPC-157-derivative compound (PL 14736) for ulcerative colitis, showing preliminary evidence of mucosal healing in human patients
Accordingly, there is a great interest in a better understanding of the underlying mechanisms disrupting glucose and lipid metabolism to discover new potential treatment targets for these conditions
