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Comment: Commenters disagreed with the CMS proposal to refine the clinical labor associated with clinical activity CA023 (Monitor patient following procedure/service, no multitasking) from 5 minutes to 0 minutes

Accurate sequence confirmation, including differentiation of isomers or isobaric variants, and structural elucidation of low-level impurities often require more advanced MS/MS techniques, such as electron-capture dissociation (ECD) or electron-transfer dissociation (ETD)

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6) data may provide interesting hints as to potential mechanism, these samples were taken at an early timepoint only 5 h after Dox treatment