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This observation raises questions about the underlying mechanisms of senescence and the necessity of addressing the root causes that drive cellular senescence, rather than merely focusing on the symptomatic removal of senescent cells

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[DOI] [PubMed] [Google Scholar] [118].Jiang D, Akopian G, Ho YS, Walsh JP, Andersen JK, Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures

At one end of the spectrum, metabolic dysfunction-associated steatotic liver (hepatic steatosis, MASL) may progress to a more advanced state called metabolic dysfunction-associated steatohepatitis (MASH) characterized by significant hepatocyte damage, inflammation, and pericellular fibrosis, and further to cirrhosis (Friedman et al

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