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Two trials in acutely hospitalized patients have shown that short-term (around 7 days) vitamin C supplementation increased concentrations of ascorbic acid in plasma and leukocytes and led to 34-35% improvements in mood state, as measured by POMS (142, 143)

It is synthesised primarily in the liver and is the most abundant endogenous (body-produced) antioxidant in human cells, with concentrations highest in hepatic, lung, kidney, and immune tissue

Mol Biol Rep 2014;41(6):3867-3879

A simple, convenient method that does not require costly instrumentation (LC, MS, and combinations) is clearly desirable for the determination of the biological concentration of SAM, and to monitor its change and metabolic paths in the body fluids, tissues and organelles

However, despite being a popular ingredient, not many are familiar with its detailed properties