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Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide

Also, the casein kinase 2 (CK2), a highly conserved serine/threonine protein kinase with dual functionality in cellular growth/proliferation and suppression of apoptosis [205], can phosphorylate NRF2 in more than ten sites within Neh4 and Neh5 domains [206], leading to NRF2 translocation to the nucleus and its activation [207]

doi: 10.1002/gepi.21965 18 BowdenJDavey SmithGBurgessS

Both DHA and erythrulose have been known to cause contact dermatitis