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In addition, the transcription factor KLF11 inhibits the proliferation of lung adenocarcinoma (LUAD) cells and promotes their chemosensitivity by participating in the GPX4-related ferroptosis pathway (37)

The major metabolic actions of dual GLP-1R/GcgR agonists are summarised in Fig

Then in January 2025, the label was updated to state that Ozempic is not recommended in patients with severe gastroparesis. But critically, the label still doesnt indicate that the drug itself may cause the condition

For example, patients with a personal or family history of thyroid cancer, pancreatitis, or certain gastrointestinal conditions may not be ideal candidates for Mounjaro

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