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Figure 3 Targeted next-generation sequencing (NGS) using a customized hybrid-capture panel covering all coding regions as well as selected intronic and promoter regions of 130 genes [as described by Sahm et al

4 had pigmentation affecting the lower limbs and 4 had pigmentation affecting the upper limbs Of the 14 patients who discontinued the doxycycline, nine reported resolution of the pigment, four reported the hyperpigmentation did not resolve, and one case outcome was not described

In non-diabetic individuals with overweight or obesity, with an average BMI of approximately 38, liraglutide administered at a dose of 3.0 mg per day for 56 weeks resulted in an 8% weight loss [10]

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Clinicians often combine epitalon with compounds like GHK-Cu (tissue and gene expression support) or mitochondrial peptides for a broader longevity protocol