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In the SURPASS-3 trial, tirzepatide showed an 8.1% reduction in MRI-measured liver fat and AST, ALT and gamma-glutamyltransferase vs

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In addition, further research is needed to clarify potential sex-specific differences and to better understand the central and peripheral mechanisms of action of GLP-1 and amylin analogues, including whether their effects are additive, synergistic, or potentially divergent in different clinical contexts

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