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Hirsch EB, Tam VH

Which semaglutide (glucagon-like peptide-1 (GLP-1) receptor agonist) option is more cost-effective: 5mg/mL (milligrams per milliliter) 2mL (milliliters) or 2.5mg/mL 4mL, given the same cost and dosing schedule of 0.25mg/weekly for 4 weeks, then 0.5mg/weekly for 4 weeks, and finally 1.00mg/weekly for 4 weeks?

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For individuals with obesity and comorbid psychological symptoms, combined outcomes such as clinically significant weight loss (e.g., 10%) and reduced binge-eating frequency or depressive symptoms are reasonable targets