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Alcohol: Alcohol consumption has a direct impact on glutathione levels, particularly in the liver, where detoxification processes occur

Using hydrogen peroxide-induced senescent TM3 Leydig cells as an in vitro model, the study confirmed that FOXO4 maintains senescent Leydig cell viability and suppresses apoptosis

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These models include those of neonatal hippocampal lesion, expression of mutant DISC1 protein and genetic deletion of the key GSH-synthesizing enzyme