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This is done to reduce gastrointestinal side effects, the FDA said

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Peak appetite suppression each week creates the conditions for calorie deficit, but actual weight loss depends on total weekly calorie balance and consistency across multiple cycles

This is the case of transferrin receptor (TfR) and low-density lipoprotein receptor (LRP1) which serve as common molecular targets on brain endothelial cells exploited by nanoparticles to enable transcytosis ( via glucose transporter-1 (GLUT1), a key mediator of cerebral glucose uptake