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Prevention is consistently more effective than treatment for reducing the overall burden of injection site reactions

Conclusions The trial did reach its primary objective

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Consistent subcutaneous placement ensures predictable dosing and reduces side effects

Abbreviations ACC: American College of Cardiology ADA: American Diabetes Association ASCVD: Atherosclerotic cardiovascular disease BMI: Body mass index CI: Confidence interval CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial DPP-4: Dipeptidyl peptidase-4 EASD: European Association for the Study of Diabetes EDTA: European Dialysis and Transplant Association eGFR: Estimated glomerular filtration rate ERA: European Renal Association ESC: Europe Society of Cardiology ESRD: End-stage renal disease EURECA-m: European Renal and Cardiovascular Medicine FDA: U.S