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Metformin activates AMPK, a key energy regulator that promotes autophagy, reduces senescent cells, and mimics the effects of caloric restrictionsupporting healthy aging and cellular repair

The bottom line GLP-1s were first FDA-approved for managing type 2 diabetes and obesity, but research is showing that they might have much wider reaching health benefits

There are some reports on using rhACE2 or angiotensin 19 and angiotensin 17 (anti-inflammatory angiotensin) to revert the impaired renin-angiotensin system back to the normal function [34, 37]

Weight loss from GLP-1 medications does not produce a disproportionate reduction in muscle mass or function in either obese mice or humans

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