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the loss is a consequence of the calorie deficit required for weight loss

Both medications require gradual titration over 3-5 months before reaching maintenance doses

Avoid excess fruit and high starch foods such as potatoes, pasta, corn, root veggies, etc

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However, whilst the IGF-1R is capable of signal transduction, the IGF-2R is not and binding results in lysosomal degradation of IGF-2