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A systematic explanation for human studies, particularly regarding the translational pathway from molecular mechanisms to clinical interventions, is still lacking

Moreover, the relationship between DN and other complications, such as cardiovascular autonomic neuropathy, has been established, indicating that these conditions often coexist and may share common pathophysiological mechanisms (de Paula et al., 2024

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A dose of 400 mg daily has been shown in randomized controlled trials to reduce migraine frequency