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Patients face these permanent life-altering consequences from NAION-related blindness: Sudden blindness in affected eye: Most experience dense altitudinal visual field loss affecting top or bottom half, with some suffering complete blindness Inability to drive or work: Vision loss severe enough to disqualify from driving and render many occupations impossible Constant risk to fellow eye: Living with approximately 15% risk over five years that the second eye will suffer identical fate No restorative treatment options: Unlike cataracts, NAION leaves patients with zero medical solutions for recovery Permanent disability from NAION has made these injuries central to litigation
After single-dose intravenous administration (0.5 g), acetyl-L-carnitine is rapidly, but not completely hydrolyzed, and acetyl-L-carnitine and L-carnitine concentrations return to baseline within 12 h
doi: 10.1126/scitranslmed.aat3392
Safety of L-Carnitine Carnitine is relatively well-tolerated but in high doses it may increase levels of trimethylamine-N-oxide (TMAO), a compound linked with an heart disease since it can increase blood pressure and the formation of plaque within the artery walls (atherosclerosis) (9)
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