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Overall, in middle-aged mice and men, GLP-1 medicines slightly decrease absolute muscle values but positively impact body composition and mobility.

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These drugs clearly are very effective, and that is fantastic, said Susan Jebb, a professor of diet and population health at the University of Oxford and one of the leaders of the project

Yet the way these new weight-loss drugs work may mean the likelihood of putting lost weight back on is even higher

More than a decade of research now shows that TCF7L2, a transcription factor regulator, impacts the production of insulin in the pancreas