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hence, glutamine levels determine the GSH/GSSG ratio by modulating GSH synthesis, which facilitates neutrophil function under oxidative stress (98)

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- and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)

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At the mRNA level, two major transcription factors have been identified that regulate stress-induced transcription of SLC7A11 , namely, Nrf2 and ATF4 (Pakos-Zebrucka et al

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Hence, whilst cysteine is one of the less common amino acids, it is often highly conserved within protein functional groups (Marino and Gladyshev, 2010)

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