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Published on January 19th, 2026

APE/Ref-1 is a paradigmatical example of this mechanism and provides a good example of the biological complexity of the system.24 APE/Ref-1 protein plays a central role in ROS-induced cellular effects, as a major member of the base excision repair (BER) pathway of DNA repair, on apurinic/apyrimidinic (AP) sites in DNA (generated as a consequence of oxidative-induced damage on DNA) and as redox controller of the activity of several important transcription factors (TFs) such as NF-B, AP-1, HIF-1 and Pax proteins