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The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: Role in cancer pathogenesis and implications for therapeutic approaches

NMN is a direct NAD+ precursor that fuels cellular energy and activates DNA repair via Sirtuin proteins

Based on the repetition ratio (RR) and the minimum energy value (MEV) inside the limiting pocket of M pro , the N3 interacts with the catalytic amino acids (CAA) and are His41, Leu141, Gly143, Ser144, Cys145, Glu166, Arg188, and Gln189, and all the internal interactions are conventional and carbon hydrogen bond type

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We tested the modified Dihexa against 200 M neomycin and observed no protection, suggesting that the current form of Dihexa has a high specificity for providing protection, likely via its specific interaction with native HGF (Figure 7)