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Partial leptin deficiency confers resistance to diet-induced obesity in mice

Although retatrutide has shown substantial weight-loss efficacy in adults with obesity, the relative contributions of reduced appetite, altered food reward, enhanced energy expenditure, and glucagon-related metabolic effects remain incompletely understood (109)

Dopamine transport, utilization, and storage may be involved in increased ROS formation followed by cellular dysfunction

This persistent neuroinflammation damages the delicate myelin sheath that insulates peripheral nerves and disrupts the delicate balance of neurotransmitters in the brain

Standard criteria use BMI 27 or higher with metabolic comorbidity