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Methods Fifteen adult albino guinea pigs were inoculated with Staphylococcus aureus and treated with saline, cefazolin sodium, or amlodipine for 7 days

Crucially, the trial also tracked what happened during a 4-week withdrawal period: patients who stopped tirzepatide began regaining weight almost immediately, losing about 50% of their initial weight loss within weeks of discontinuation

This setback reflects broader challenges associated with therapies targeting the amyloid-beta pathway, which has dominated Alzheimers research for decades

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