Similarly, in the SURMOUNT-4 trial, participants who discontinued tirzepatide after 36 weeks regained 14%-points of body weight, while those who continued treatment achieved an additional 5.5% weight loss [69]
Another study of 125,474 people with obesity or who are overweight found that almost 47% of those with Type 2 diabetes and nearly 65% of those without diabetes stopped taking GLP-1s within a year a high rate, said Ezekiel Emanuel, a health services researcher at the University of Pennsylvania and senior author of the study
Dietary Modifications: Balanced Diet: A nutrient-rich diet emphasizing whole, unprocessed foods, including vegetables, lean proteins, and healthy fats, supports metabolic health while minimizing sugar and refined carbohydrates
This can occur during significant calorie restriction or carbohydrate limitation whilst taking Wegovy, particularly in patients with diabetes who should seek medical advice if this occurs alongside thirst, fatigue, or confusion
Together, these results highlight the robustness and adaptability of PfFt as a scaffold for modular vaccine design