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Moreover, combination therapies have demonstrated significant advantages, such as Novo Nordisks CagriSema (semaglutide + cagrilintide), which shows superior glycemic control and weight reduction effects compared to semaglutide alone, demonstrating that combination therapy can achieve more than the sum of its parts while reducing side effects

Yes, that aspect is probably one of the factors that generate those wide uncertainty bands

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The average well-managed patient should lose around 10% to 15% of their total body weight within the first year on the medication at its maximum dose