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Interestingly, the STAT3 transcription factor is the major inducer of the expression of this immunosuppressive armament, either directly or indirectly [9, 89, 93, 94]
Decreases in body weight, BMI, and waist circumference Improved insulin sensitivity and blood sugar control Reduced total testosterone levels More regular menstrual cycles and higher rates of natural ovulation Theres also evidence that combining GLP-1s with metformin, a long-standing insulin-sensitizing medication, may amplify these benefits, especially for women whove struggled to lose weight on metformin alone
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