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However, most cases occurred in patients with a shock state and/or tissue hypoxia or in the presence of several other predisposing conditions like impaired renal function and heart failure (Table 10.3)

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Trauma can lead to nightmares, hypervigilance, and fragmented sleep

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The present study is therefore based on the hypothesis that disulfide formation is critical in the pathogenesis, and to emphasise the presence of a disulfide bond, NNTTR will hereafter be referred to as dsNNTTR