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Preclinical studies have used various neurotoxin-based models to mimic the oxidative stress and dopaminergic neurodegeneration observed in PD

Notably, fosgonimetons Phase 2/3 LIFT-AD trial in mild-to-moderate Alzheimers disease missed its primary endpoint in topline results released in 2023

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doi: 10.3322/caac.21660 2 VitekLHubacekJAPajakADoryskaAKozelaMEremiasovaLet al

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