not feeling anything on semaglutide Why am I losing weight (Ozempic/Wegovy)? Why Semaglutide Stopped Working: 5

They were originally designed for folks with Type 2 Diabetes for the purpose of blood sugar regulation

Lancet 2004;364:1789-1799 Kennedy S, Bergqvist A, Charon C, et al

Some patients continue for over six months depending on the amount of weight they want to lose

Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): A multicentre international randomised controlled trial

The Pharmaceutical Journal states explicitly: "There is no validated dose equivalence between the two agents owing to their differing receptor profiles." Even patients who were stable on semaglutide 2.4mg (Wegovy maximum) must begin tirzepatide at 2.5mg once weekly and titrate per the standard schedule