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Scientific and institutional sources All figures and dates cited in this comparison are based on published clinical trials and the following official opinions, verified on May 8, 2026

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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

However, unlike these peptides, PRP has been studied extensively in humans and has a strong safety profile overall, although its not risk-free