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The calcium-binding affinity of S100 proteins is low in the absence of target proteins, but the affinity is significantly increased by several orders of magnitude in the presence of specific target proteins ( Figure 1 The 3D structures of S100 protein family have been resolved in three different states: Ca 2+ -free apo state, bound to Ca 2+ and bound to its target protein ( Because of multiple functions of the S100 proteins, many diseases, including psoriasis, are associated with altered expression levels of S100 proteins

Cancer-targeted chitosanbiotin-conjugated mesoporous silica nanoparticles as carriers of zinc complexes to achieve enhanced chemotherapy in vitro and in vivo

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The company has scrambled to expand production and has already scaled manufacturing in the past three years to triple the number of patients reached from 4 million to 12 million