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As early as 1959, it was recognized that the SEC-based fractionation of macromolecules is determined by their molecular sizes (Porath and Flodin, 1959)

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However, ketone bodies are acidic, and very high levels of these compounds in the blood are toxic and may result in ketoacidosis (5)

Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life

PMID 16267554