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The majority of the menopausal women experienced a hot flash within minutes of inhaling 20% CO2.[ref] Sleep apnea: Along the same lines of breath holding and CO2 rising, sleep apnea is also associated with increased hot flashes.[ref] Chronic inflammation and more intense hot flashes: Researchers have found that the intensity of hot flashes is associated with higher levels of inflammatory cytokines (IL-8 and TNF-alpha)

It is freely soluble in water at a normal pH, a property that simplifies its formulation and administration

Once TGR5 is activated, BAs may suppress the production of inflammatory cytokines such as IL-1, IL-6, and TNF- (302)

Consistency over time matters more than perfect daily adherence

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