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It is a high-maintenance solution to a persistent issue

483,484,485 PPAR- agonists (thiazolidinediones and TZDs) used for diabetes mellitus, which enhance adipocyte lipid storage, decrease ectopic lipid accumulation and improve insulin sensitivity in liver and skeletal muscles

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The model compares combined treatment against GLP-1 therapy alone over 10-year and 30-year horizons