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Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

IV glutathione replenishes cellular stores rapidly, supporting both liver detox pathways and systemic toxin elimination

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Post-Exertional Malaise (PEM) Triggers: While PEM is primarily driven by physical or cognitive exertion, severe dietary immune reactions act as massive physiological stressors that can lower the threshold for a crash