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There are other problems associated with traditional antibiotic discovery methods, including the search for amplification of known chemical scaffolds, low access to new chemical varieties, and essentially a focus on individual bacterial cells, which may not be effective concerning the bacterial preference of forming colonies and even biofilms with different bacterial species [56]

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The carriers of the loss-of-function GIP receptor variants, R190Q and E288G, display higher blood pressure and an increased tendency toward hypertension (99) but a comprehensive study of larger number of loss-of-function GIP receptor variants did not reveal similar effects on cardiovascular traits (39)

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doi: 10.1212/WNL.0000000000200787 67