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4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied on in vitro mesangial cell models and lack validated animal models that fully recapitulate human IgA nephropathys pathological features (e.g., glomerular IgA1 deposition and mesangial proliferation)

doi: 10.1159/000066263 67 SiemensmaEPCde Lind van WijngaardenRFAOttenBJde JongFHHokken-KoelegaACS