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Further research has shown that TPC2 counterbalances OCA2, a positive regulator of pigmentation, by increasing the melanosomal membrane potential to decrease melanin content

A separate study using daily dosing for 8 consecutive days produced hyperpigmentation in 38% of participants

Clinical trial data published in the New England Journal of Medicine found that tirzepatide produced meaningfully greater weight loss than semaglutide on average in patients with obesity

Permanent follicular damage is not expected with this type of shedding, though persistent or patchy loss should be assessed by a GP to rule out other causes