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In doing so, the review explores the epidemiology, underlying mechanisms, and current dietary and lifestyle-based management strategies by synthesizing existing knowledge and highlighting key discoveries, this review aims to illuminate the complexities of MetS and guide future interventions and research directions

Note that routine amylase/lipase monitoring is not recommended in asymptomatic patients

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Orforglipron Phase 3 data showed gallbladder-related events at rates modestly above placebo, consistent with the class effect

They work best when combined with a consistent, challenging workout regimen and an adequate nutrition plan