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The pair, along with colleague John Eng, identified a hormone-like molecule in the venom called exendin-4, which stimulated insulin secretion using the same receptor as a human gut hormone called GLP-1 (glucagon-like peptide 1)

Cardiac SLU-PP-332: Xu et al., Circulation 2023 (PMID 37961903) showed pan-ERR agonism improved ejection fraction and reduced fibrosis in mouse pressure-overload heart failure

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We thus used this approach to selectively stimulate L-cells in primary colonic cultures derived from mice with Gq-DREADD expression under the control of the proglucagon promoter