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This FOXO4-p53 interaction occurs within nuclear PML (promyelocytic leukemia) bodies and is critical for maintaining the viability of senescent cells without it, p53 is free to translocate to mitochondria and trigger intrinsic apoptosis

Weight alone is misleading

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This is insane. While its important to note that the study still needs to be finalized and reviewed before any of this is official, its okay to get excited

These findings led to Phase I and II clinical trials of T4 eyedrops (RGN-259) for dry eye and neurotrophic keratopathy, making the ocular surface one of the most clinically advanced use areas for the broader T4/TB-500 compound class