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This is largely due to delayed diagnosis leading to detection in the advanced stages

A common pattern is modest initial loss (partly water weight, partly from reduced intake), followed by a slower-looking middle period where fat loss is happening but the scale isn't moving dramatically

Treatment includes supportive measures, discontinuation of any offending drugs and, in severe cases, haemodialysis can accelerate clearance of the acid

With studies suggesting that glutathione from food sources can be challenging for the body to absorb, supplementation may be more effective

Over the next 48 weeks, those who stayed on semaglutide lost a further 7.9%, whereas those switched to placebo regained 6.9%