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J., Carlsson, B

Int J Sport Nutrit Exer Metabol 1(aop):19 Wax B, Kavazis AN, Weldon K, Sperlak J (2015) Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters

There's no controlled research establishing that dose or frequency changes the likelihood of this reported effect, but the most consistently recommended practical step across community discussion is starting at a reduced frequency, two to three times a week rather than daily, for the first couple of weeks, then building up gradually

Microstructural analysis of feeding behavior reveals tesofensine significantly reduces total number of meals, average meal size, and average meal duration while dramatically increasing latency to first meal

Studies in cultured hepatocytes and in vivo