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A Phase 1 clinical trial of the MOTS-C analog CB4211 found the compound safe after 7 days of dosing, though persistent mild injection site bumps were noted

You may also experience throat discomfort/soreness and sensation of fullness in the back of the throat after submental or submandibular area treatment

There are many nuances and complexities here, and the full truth is yet to be revealed

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To more directly test for a potential microbial contribution to the observed d9-carnitine in plasma following d9-BB ingestion, we quantified the production of d9-carnitine (and d9-betaine) from d9-BB in freshly harvested gut segments incubated ex vivo under either aerobic or anaerobic conditions