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The underlying mechanism for this phenomenon is presumably the persistent dysregulation of energy homeostasis caused by MC4R deficiency, which cannot be fully reversed by bariatric surgery alone, leading to excessive food intake and subsequent weight regain over time

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When to Talk to a Provider You should consult a qualified provider if you experience: Persistent side effects beyond two weeks Increasing swelling or discomfort Changes in blood sugar or energy that feel abnormal Any symptom that causes concern Often, small adjustments can significantly improve tolerability