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Discuss: Your target weight loss and timeframe How weight loss might affect your inflammatory condition Whether weight management could potentially reduce disease activity or medication requirements Realistic expectations about side effects and how these will be managed Monitoring plans need to be agreed upon, including: Frequency of follow-up appointments Which healthcare professional will oversee each aspect of your care What symptoms should trigger urgent contact Blood test schedules and other investigations Practical administration questions should be addressed: Optimal timing for each injection Injection site rotation strategies Storage requirements for both medications What to do if you miss a dose of either medicine Travel considerations if you need to transport injectable medications Pregnancy planning is crucial, as both medications have implications for pregnancy and breastfeeding

doi: 10.1038/s41586-021-03819-2 23 JungK.JungH.KleberH

While subsequent studies highlighted heightened suicide risk in children under the age of 18, there was no increased risk for adults over 24 years old

Indeed, some people have reported feeling depressed due to semaglutide